Publications and Patents

Sensitive and label-free biosensing of RNA with predicted secondary structures by a triplex affinity capture method 

Laura G. Carrascosa; S. Gomez-Montes; A. Avino; A. Nadal; M. Pla; R. Eritja; L. M. Lechuga

Nucleic Acids Research 2012 (advance access)

• http://pubs.acs.org/doi/abs/10.1021/nn203432z

Light propagation in single mode polymer nanotubes

N. Huby, J.-L. Duvail, D. Duval and B. Bêche

Appl Phys Lett 99 (11) (2011) pp.113302/1-3

DOI 10.1063/1.3637043

This article has been selected for the Virtual Journal of Nanoscale Science & Technology, 24 (13), 2011

• http://apl.aip.org/resource/1/applab/v99/i11/p113302_s1

Integrated Optical Devices for Lab-on-a-chip Biosensing Applications

M.-Carmen Estevez, Mar Alvarez and Laura M. Lechuga

Laser and Photonics Reviews, in Press.

DOI 10.1002/lpor.201100025

Integrated Bimodal Waveguide Interferometric Biosensor for Label-free Analysis

K. E. Zinoviev, A. B. González-Guerrero, C. Domínguez and L. M. Lechuga

J. LightwaveTech. 29 (2011) 1926-1930

doi: 10.1109/JLT.2011.2150734

Technical Advance: Surface plasmon resonance-based analysis of CXCL12 binding using immobilized lentiviral particles

Vega B, Muñoz LM, Holgado BL, Lucas P, Rodríguez-Frade JM, Calle A, Rodríguez-Fernández JL, Lechuga LM, Rodríguez JF, Gutiérrez-Gallego R, Mellado M.

J. Leukoc. Biol. 90: 399-408; 2011

doi: 10.1189/jlb.1010-565

• http://www.jleukbio.org/content/early/2011/05/16/jlb.1010-565.long

Suitable combination of noble/ferromagnetic metal multilayers for enhanced magneto-plasmonic biosensing

David Regatos, Borja Sepúlveda, David Fariña, Laura G. Carrascosa, and Laura M. Lechuga

Optics Express 19, 8336-8346 (2011) 

doi:10.1364/OE.19.008336

• http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-9-8336

Improved Biosensing with Novel Suspended Nanodisks

M.A.Otte, M.-C.Estévez, L.G.Carrascosa, A.B.González Guerrero, L.M.Lechuga, B.Sepúlveda

Journal of Physical Chemistry C (2011), 115 (13), 5344-5351

doi: 10.1021/jp110363a

• http://pubs.acs.org/doi/abs/10.1021/jp110363a

Au/Fe/Au multilayer transducers for Magneto-Optic Surface Plasmon Resonance sensing

D.Regatos, D. Fariña, A. Calle, A. Cebollada, B. Sepúlveda, G. Armelles and L.M. Lechuga

 J. Appl. Phys. 108, 1 (2010)

doi:10.1063/1.3475711

• http://jap.aip.org/resource/1/japiau/v108/i5/p054502_s1

Understanding the role of thiol and disulfide self-assembled DNA receptor monolayers for biosensing applications.

Laura G. Carrascosa, Lidia Martínez, Yves Huttel, Elisa Román and Laura M. Lechuga

European Biophysics Journal, 2010 Sept; 39 (10): 1433-44 

DOI 10.1007/s00249-010-0599-6

http://www.springerlink.com/content/n07152j58h3k5704/

Optical Forces in Plasmonic Nanoparticle Dimers

Vladimir D. Miljkovic, Tavakol Pakizeh, Borja Sepulveda, Peter Johansson and Mikael Kall

Journal of Physical Chemistry C, ASAP 2010 

doi: 10.1021/jp911371r 

• http://pubs.acs.org/doi/pdf/10.1021/jp911371r

Plasmon-Induced Magneto-Optical Activity in Nanosized Gold Disks

B. Sepulveda, J. B. Gonzalez-Dıaz, A. Garcıa-Martın, L. M. Lechuga and G. Armelles

Physical Review Letters 104, 147401 (2010)

doi: 10.1103/PhysRevLett.104.147401

• http://prl.aps.org/pdf/PRL/v104/i14/e147401

 Identification of the Optimal Spectral Region for Plasmonic and Nanoplasmonic Sensing

M.A. Otte, B. Sepúlveda, W. Ni, J. Pérez-Juste, L.M. Liz-Marzán, L.M. Lechuga

ACS Nano (2010), 4 (1), 349-357

• http://pubs.acs.org/doi/abs/10.1021/nn901024e

Influence of the linker type on the Au-S binding properties of thiol and disulfide-modified DNA self-assembly on polycrystalline gold.

Lidia Martínez, Laura G. Carrascosa, Yves Huttel, Laura M. Lechuga and Elisa Román.

Phys. Chem. Chem. Phys. 2010, 12: 3301-3308

doi:10.1039/b924504a

Microcantielver-based platforms as biosensing tools

M. Alvarez and L. M. Lechuga

Analyst 135 (2010) 827 - 836

doi: 10.1039/b908503n

Surface Plasmon Resonance Biosensors for highly sensitive detection in real samples

B. Sepúlveda, L.G. Carrascosa, D. Regatos, M.A. Otte, D. Fariña and L.M. Lechuga

Proceed. SPIE Photonics and Optics 7397 (2009) 73970Y-11

doi: 10.1117/12.827062

Plasma-activated multiwalled carbon nanotube-polystyrene composite substrates for biosensing

C. Fernández-Sánchez, E. Pellicer, J. Orozco, C. Jiménez-Jorquera, L.M. Lechuga and Ernest Mendoza

Nanotechnology 20 (2009) 335501-335508

doi:10.1088/0957-4484/20/33/335501

Single and multi-analyte determination of gonadotropic hormones in urine by Surface Plasmon Resonance immunoassay

J. Treviño, A. Calle, J.M. Rodriguez-Frade, M. Mellado and L.M. Lechuga.

Anal. Chim. Acta 647 (2009) 202-209

doi:10.1016/j.aca.2009.06.002

Surface plasmon resonance immunoassay analysis of pituitary hormones in urine and serum samples.

J. Treviño, A. Calle, J.M. Rodriguez-Frade, M. Mellado and L.M. Lechuga.

Clin. Chim. Acta 403 (2009) 56-62

doi:10.1016/j.cca.2009.01.015

Sensitivity Enhancement of Nanoplasmonic Sensors in Low Refractive Index Substrates

Björn Brian, Borja Sepúlveda, Yury Alaverdyan, L. M. Lechuga, Mikael Käll

Optics Express 17:3 (2009) 2015 – 2023

doi:10.1364/OE.17.002015

LSPR-based nanobiosensors

B. Sepúlveda, P.C. Angelomé, L.M. Lechuga and L.M. Liz-Marzán

Nanotoday 4 (2009) 244-251

doi:10.1016/j.nantod.2009.04.001

Determination of human growth hormone in blood serum samples by Surface Plasmon Resonance immunoassay.  

J. Treviño, A. Calle, J.M. Rodríguez-Frade, M. Mellado and L.M. Lechuga.  

Talanta 78 (2009) 1011-1016

doi:10.1016/j.talanta.2009.01.012

Biosensing microsystem platforms based on the integration of Si Mach-Zehnder interferometer, microfluidics and grating couplers.

L. M. Lechuga, K. Zinoviev, O. Hidalgo, L. Fernández, J. Elizalde and C. Domínguez.

Proceed. SPIE Photonics West, 2009

Label-free detection of DNA mutations by SPR: application to the early detection of inherited breast cancer

L.G. Carrascosa, A. Calle and L.M. Lechuga

Anal. Bioanal. Chem. (2009), 393 (4), 1173

doi: 10.1007/s00216-008-2555-1

Assessment of catalyst particle removal in multi-wall carbon nanotubes by highly sensitive magnetic measurements

E. Pellicer, A.B. Gonzalez-Guerrero, J. Nogues, L.M. Lechuga, E. Mendoza

Carbon 47 (2009) 758-763

doi:10.1016/j.carbon.2008.11.007

Biosensing microsystem platforms based on the integration of Si Mach-Zehnder interferometer, microfluidics and grating couplers

L. M. Lechuga, K. Zinoviev, O. Hidalgo, C. Domínguez, J. Elizalde

Proceedings of the SPIE 7220 (2009) 72200L-72200L-8

doi:10.1117/12.809166

Label-Free Pathogen Detection with Sensor Chips Assembled from Peptide Nanotubes

Roberto de la Rica, Ernest Mendoza, Laura M. Lechuga, Hiroshi Matsu

Angewandte Chemie 47:50 (2008) 9752 – 9755

doi: 10.1002/ange.200804299

Discriminating the carboxylic groups from the total acidic sites in oxidized multi-wall carbon nanotubes by means of acid-base titration

A. Gonzalez-Guerrero, E. Pellicer, F. Alsina, C. Fernández-Sánchez and L.M. Lechuga

Chemical Physics Letters 462 (2008) 256-259

doi:10.1016/j.cplett.2008.07.071

La revolución de la Nanomedicina
L.M. Lechuga
Revista SEDISA, 38-43, 2008

Magneto-optic sensitivity enhancement in plasmonic sensors

B. Sepúlveda, A. Calle, L.M. Lechuga and G. Armelles

BioWorld Europe (The magazine for the life science industry in Europe) 01 (2008) 12-14

 Silicon Photonics Biosensors for “lab-on-a-chip” applications (Invited paper, Special Issue on Silicon Photonics). K. Zinoviev, L.G. Carrascosa, J. Sánchez del Río, B. Sepúlveda, C. Domínguez and L.M. Lechuga.

Advances in Optical Technologies 2008 (2008) article ID 383927

doi:10.1155/2008/383927

 Scalable fabrication of Immunosensors based on Carbon Nanotube Polymer Composites

E. Mendoza, J. Orozco, C. Jiménez-Jorquera, A. B.González-Guerrero, A. Calle, L. M. Lechuga and C. Fernández-Sánchez

Nanotechnology 19 (2008) 075102

doi:10.1088/0957-4484/19/7/075102

Optical waveguide cantilever actuated by light

K. Zinoviev, C. Dominguez, J. A. Plaza, and L. M. Lechuga

Appl. Phys. Lett. 92 (2008)  011908

doi: 10.1063/1.2830818

Biosensor devices

L.M. Lechuga

Proceed. Advanced Summer School in Physics 2007. Frontiers in Contemporary Physics- EAV07. AIP Conference Proceedings 960 (2007) 186-202

doi: 10.1063/1.2825120

Lab-on-a-chip platforms based on highly sensitive nanophotonic Si biosensors for single nucleotide DNA testing

J. Sánchez del Río, L. G. Carrascosa, M. Moreno, F.J. Blanco, J. Berganzo, A. Calle, C. Domínguez and L. M. Lechuga

Proceed. SPIE Photonics West 6477 (2007) 64771B

doi: 10.1117/12.713977

On-line determination of 3,5,6-trichloro-2-Pyridinol in human urine samples by Surface Plasmon Resonance immunosensing

E. Mauriz, A.Calle, J.J. Manclús, A. Montoya, and L. M. Lechuga

Anal. Bioanal. Chem. 387 (2007) 2757-2765

doi: 10.1007/s00216-007-1175-5

Optical biosensor based on arrays of waveguide microcantilevers

K. Zinoviev, J.A. Plaza, V. Cadarso, C. Domínguez and L. M. Lechuga

Proceed. SPIE Photonics West 6477 (2007) 64771A

doi: 10.1117/12.698176

Pulsed electroluminescence in silicon nanocrystals-based devices fabricated by PECVD

J. Barreto, M. Perálvarez, J.A. Rodríguez, A. Morales, M. Riera, M. López, B. Garrido, L.M. Lechuga and C. Domínguez

Physica E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES 38 (2007) 193-196

doi: 10.1016/j.physe.2006.12.015

Part per trillion determination of atrazine in natural water samples by a Surface Plasmon Resonance immunosensor

M. Farré, E. Martínez, J. Ramón, A. Navarro, J. Radjenovic, E. Mauriz, L. M. Lechuga, M.P. Marco and D. Barceló

Anal. Bioanal. Chem. 388 (2007) 207-214

doi: 10.1007/s00216-007-1214-2

Magnetooptical phase modulation in integrated Mach-Zehnder interferometric biosensors

B. Sepúlveda, G. Armelles and L. M. Lechuga

Sensors and Actuators A 134 (2007) 339-347

doi: 10.1016/j.sna.2006.05.046

Optical Immunosensor for fast and sensitive detection of DDT and related compounds in river water samples

E. Mauriz, A. Calle, A. Abad, A. Montoya, A. Hildebrandt, D. Barceló and L.M. Lechuga

Biosensors & Bioelectronics 22 (2007) 1410-1418

doi:10.1016/j.bios.2006.06.016

Multi-analyte SPR immunoassay for enviromental biosensing of pesticide

E. Mauriz, A.Calle, J.J. Manclús, A. Montoya, and L. M. Lechuga

Anal. Bioanal. Chem. 387 (2007) 1449-1458

doi: 10.1007/s00216-006-0800-z

Micro and nano immunosensors: Technology and Applications

L. M. Lechuga

Analytical and Bioanalytical Chemistry 384 (2006) 44- 46

doi: 10.1007/s00216-005-0180-9

Determination of carbaryl in natural water samples by a Surface Plasmon Resonance flow-through immunosensor

E. Mauriz, A. Calle, A. Abad, A. Montoya, A. Hildebrandt, D. Barceló and L. M. Lechuga

Biosensors & Bioelectronics 21(2006) 2129-2136

doi: 016/j.bios.2005.10.013

Magnetooptic effects in surface plasmon-polaritons slab waveguides

B. Sepúlveda, L. M.Lechuga and G. Armelles

J. of Lightwave Tech. 24 (2006) 945-955

doi: 109/JLT.2005.861943

Dimension dependence of the thermomechanical noise of microcantilevers

M. Alvarez, J. Tamayo, J. A. Plaza, K. Zinoviev, C. Dominguez and L. M. Lechuga

J. Appl. Physics 99 (2006) 024910

doi:10.1063/1.2164537

Light coupling into an optical microcantilever by an embedded diffraction grating

K. Zinoviev, C. Dominguez, J. A. Plaza and L. M. Lechuga

Applied Optics 45 (2006) 229-234

doi:10.1364/AO.45.000229

Real-time detection of chlorpyrifos at part per trillion levels in ground, surface and drinking water samples by a portable Surface Plasmon Resonance immunosensor

E. Mauriz, A.Calle, and L. M. Lechuga, J. Quintana, A. Montoya, J. J. Manclús

Anal. Chim. Acta 561 (2006) 40-47

doi:10.1016/j.aca.2005.12.069

Highly sensitive detection of biomolecules with the magneto-optic Surface Plasmon Resonance sensor

B. Sepúlveda, A. Calle, L. M. Lechuga and G. Armelles

Optics Letters 31 (2006) 1085-1087

doi: 10.1364/OL.31.001085

This article has been highlighted in the MRS Bulletin (Material Research Society), 31, 6, June 2006

A novel optical waveguide microcantilever sensor for the detection of nanomechanical forces

K. Zinoviev, C. Dominguez, J.A. Plaza, V. Cadarso and L. M. Lechuga.

J. Lightwave Tech. 25 (2006) 2132-2138

doi: 10.1109/JLT.2006.872315

Microfluidic-Optical Integrated CMOS compatible devices for label-free biochemical sensing

F. J. Blanco, J Berganzo, M. Agirregabiria, K. Mayora, J. Elizalde, A. Calle, C. Dominguez and L. M. Lechuga

J. of Micromechanics and Microengineering 16 (2006) 1006-1016

doi: 10.1088/0960-1317/16/5/018

Optical biosensor microsystems based on the integration of higly sensitive Mach-Zehnder interferometer devices

B. Sepúlveda, J. Sánchez del Río, M. Moreno, F.J. Blanco, C. Domínguez and L. M. Lechuga

J. of Optics A: Pure and Applied Optics 8 (2006) S561-S566

doi: 10.1088/1464-4258/8/7/S41

Determination of environmental organic pollutants with a portable optical immunosensor

E. Mauriz, A. Calle, A. Montoya and L. M. Lechuga

Talanta 69 (2006) 359-36

doi: 10.1016/j.talanta.2005.09.049

Single and Multi-analyte Surface Plasmon Resonance assays for simultaneous detection of cholinesterase inhibiting pesticides

E. Mauriz, A.Calle, J.J. Manclús, A. Montoya, A. M. Escuela, J.R. Sendra and L. M. Lechuga

Sensors and Actuators B 118 (2006) 399-407

doi: 10.1016/j.snb.2006.04.085

Optoelectronics sensors applied to Biology

L. M. Lechuga, E. Mauriz, B. Sepúlveda, J. Sánchez del Río, A. Llobera, A. Calle and C. Domínguez

Óptica Pura y Aplicada. 39 (2006) 129-133

A highly sensitive microsystem based on nanomechanical biosensors for Genomics applications

L.M. Lechuga, J. Tamayo, M. Álvarez, L.G. Carrascosa, A. Yufera, R. Doldán, E. Peralías, A. Rueda, J.A. Plaza, K. Zinoviev, C Domínguez, A. Zaballos, M. Moreno, C. Martínez-A, D. Wenn, N. Harris, C. Bringer, V. Bardinal, T. Camps, C. Vergnenègre, C. Fontaine, V. Díaz and A. Bernad

Sensors and Actuators B. 118 (2006) 2-10

doi: 10.1016/j.snb.2006.04.017

Article highlighted in the Nanotech News of the National Cancer Institute (US)

Article highlighted in the News Web section of the Nano Science and Technology Institute (NSTI)

T-shaped microcantilever with reduced deflection offset valuable for chemical and biomedical detection

J. A. Plaza, K. Zinoviev, G. Villanueva, M. Álvarez, J. Tamayo, C. Domínguez and L. M. Lechuga

Appl. Phy. Lett. 89 (2006) 094109

doi: 10.1063/1.2345234

Article selected for the September 11, 2006 issue of Virtual Journal of Nanoscale Science & Technology Article selected for the September 1, 2006 issue of Virtual Journal of Biological Physics Research

Butt coupled microcantilever in sensing applications

K. Zinoviev, J.A. Plaza, V. Cadarso, L. M. Lechuga and C. Domínguez

Proceed. SPIE Photonics Europe 6186 (2006) 618607

doi: 10.1117/12.662393

Nanobiotecnología: avances diagnósticos y terapéuticos

Laura M. Lechuga

Revista de Investigación en Gestión de la Ciencia y la Tecnología. Mi+d. Nanociencia y Nanotecnología II 35 (2006).

www.madrimasd.org/revista/revista35/tribuna/tribuna2.asp

Nanomechanical biosensors: a new sensing tool

L.G. Carrascosa, M. Moreno, M. Alvarez and L. M. Lechuga

Trends in Anal. Chem (TRAC) 25 (2006) 196-206

doi: 10.1016/j.trac.2005.09.006

Nanobiotechnologies to provide a portable genetic biosensor device

L.M. Lechuga

Asia-PacificBiotech News 9 (2005) 1130-1131

Optical sequential readout of microcantilevers arrays for biological detection

M. Alvarez and J. Tamayo

Sensors and Actuators B 106 (2005) 687

doi:10.1016/j.snb.2004.09.016

3D Polymeric Microfluidics networks for BioMEMS applications

J. Blanco, J. García, K. Mayora, A. Calle, C. Domínguez and L. M. Lechuga

Proceed. SPIE International Symposium on Microtechnologies for the New Millennium 5839 (2005) 127- 137

Highly sensitive polymer-based cantilever-sensors for DNA detection

M. Calleja, M. Nordström, M. Alvarez, J. Tamayo, L. M. Lechuga, A. Boisen

Ultramicroscopy 105 (2005) 215-222

doi: 10.1016/j.ultramic.2005.06.039

La resonancia de plasmón: una técnica revolucionaria en el estudio de interacciones dinámicas superficiales

M. R. Aguilar, A. Gallardo, L. M. Lechuga, A. Calle y J. San Román

Revista de Plásticos Modernos 571 (2004) 62-70

Integrated micro- and nano-optical biosensor silicon devices CMOS compatible

L. M. Lechuga; B. Sepulveda ; J. Sanchez del Rio ; F. Blanco ; A. Calle; C. Dominguez

Proceed. of the SPIE, Integrated Optoelectronics Devices 5357 (2004) 96-110

doi: 10.1117/12.521104

Matrix Analysis of Discontinuities in Non-Reciprocal Waveguides: Analytical Description for Magneto-Optical Slab Waveguides

B. Sepulveda and L. M. Lechuga

J. Lightwave Technology. 22 (2004) 1772-1781

doi: 10.1109/JLT.2004.831094

Modulation of proteins adsorption onto the surface of chitosan complexed with anionic copolymers. Real time analysis by surface plasmon resonance

M. R. Aguilar, A. Gallardo, L. M.Lechuga, A. Calle and J. San Román

Macromolecular Bioscience 4 (2004) 631-638

doi: 10.1002/mabi.200400039

Nanomechanics of the formation of DNA self-assembled monolayers and hybridisation on microcantilevers

M. Alvarez, L.G. Carrascosa, M. Moreno, A. Calle, A. Zaballos, L. M. Lechuga, C. Martínez-A and J. Tamayo

Langmuir 20 (2004) 9663-9669

doi: 10.1021/la0489559

Integrated Mach-Zehnder Interferometer based on ARROW structures for biosensor applications

F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez and L.M. Lechuga

Sensors and Actuators B 92 (2003) 151-158

doi: 10.1016/S0925-4005(03)00257-0

Development of Nanomechanical biosensors for the detection of the pesticide DDT

M. Alvarez, A. Calle, J. Tamayo, A. Abad, A. Montoya and L. M. Lechuga

Biosensors & Bioelectronics 18 (2003) 649-653

doi: 10.1016/S0956-5663(03)00035-

An integrated Optical interferometric Nanodevice based on silicon technology for biosensor applications

F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya and L. M. Lechuga

Nanotechnology. 14 (2003) 907-912

doi: 10.1088/0957-4484/14/8/312

Polymeric cantilever arrays for biosensing applications

M. Calleja, J. Tamayo, A. Johansson, P. Rasmussen, L. M. Lechuga and A. Boisen

Sensors Letters 1 (2003) 20-24

doi: 10.1166/sl.2003.010

Decrease of the resonance bandwidth of micromechanical oscillators by phase-control of the driving force

J.Tamayo and L.M. Lechuga

Appl. Phys. Lett. 82 (2003) 2919-2921

doi: 10.1063/1.1571228

Nanomechanics for specific biological detection

M. Alvarez, L.G.Carrascosa, J.Tamayo, A.Calle and L. M. Lechuga

Proceed. of SPIE. Microtechnologies for the New Millennium 2003: Nanotechnologies 5118 (2003) 197-206

doi: 10.1117/12.498629

Integrated optical silicon IC compatible nanodevices for biosensing applications

L. M. Lechuga, B. Sepúlveda, A. Llobera, A. Calle and C. Domínguez

Proceed. of SPIE. Microtechnologies for the New Millennium 2003: Bioengineered and Bioinspired System 5119 (2003) 140-148

doi: 10.1117/12.497470

Digital tuning of the quality factor of micromechanical resonant biological detectors

J. Tamayo, M. Álvarez and L.M. Lechuga

Sensors and Actuators B 89 (2002) 33-39

doi:10.1016/S0925-4005(02)00424-0

Optimized Silicon Antiresonant Reflecting Optical Waveguides for sensing applications

F. Prieto, L.M. Lechuga, A. Calle, A. Llobera and C Domínguez

J. Lightwave Tech. 19 (2001) 75-83

doi: 10.1109/50.914488

Optical sensors based on evanescent field sensing. Part I.Surface Plasmon Resonance Sensors

L.M. Lechuga, A. Calle and F. Prieto

Química Analítica 19 (2000) 54- 60

Optical sensors based on evanescent field sensing. Part II. Integrated Optical Sensors

L.M. Lechuga

Química Analítica 19 (2000) 61- 67

Design and analysis of silicon antiresonant reflecting optical waveguides for evanescent field sensor

F. Prieto, A. Llobera, D. Jiménez, A. Calle, C Domínguez and L. M. Lechuga

J. Lightwave Tech. 18 (2000) 966-972

doi: 10.1109/50.850742